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Plasma Cell Pododermatitis

Immune-mediated foot pad disease in cats (pillow foot) with characteristic mushy, swollen pads.

Key Facts

  • Classic 'mushy' balloning appearance of foot pads
  • Multiple feet affected (usually not just one)
  • ~50% of affected cats are FIV-positive
  • Immune-mediated basis with plasma cell infiltration
  • Doxycycline is treatment of choice (immunomodulating properties)
  • ~50% respond after 2 months of doxycycline
  • Prednisolone or cyclosporine for non-responders

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