Condition2 connections · 1 source
Nsaid Toxicity
Poisoning resulting from the ingestion of non-steroidal anti-inflammatory drugs intended for humans, such as ibuprofen, naproxen, and aspirin.
Key Facts
- NSAIDs inhibit cyclooxygenase enzymes, leading to gastrointestinal ulceration, renal failure, and central nervous system depression in pets.
- Cats are particularly sensitive to NSAID toxicity due to deficient glucuronidation pathways in their livers.
- Even small doses of baby aspirin or ibuprofen can cause severe organ damage in dogs and cats.
- Treatment typically involves aggressive intravenous fluid therapy, gastroprotectants, and sometimes dialysis for severe renal compromise.